College football odds, picks, predictions, best bets for Week 4, 2022: Proven model likes USC, Texas

The Tennessee Vols have never been favored by more than a touchdown against the Florida Gators, but that is set to change when they square off on Saturday afternoon at Neyland Stadium. No. 11 Tennessee is a 10.5-point favorite in the latest Week 4 college football odds at Caesars Sportsbook, while the over/under is 62.5 for that 3:30 p.m. ET SEC on CBS matchup. The Vols are coming off a 63-6 win over Akron, and they have now covered the spread in all three of their wins this season. Should you be backing them with your Week 4 college football bets?

Another marquee game on the Week 4 college football schedule features No. 21 Wake Forest hosting No. 5 Clemson. The Tigers, who are coming off a 48-20 win over Louisiana Tech, are 7-point road favorites in the Week 4 college football spreads. Before locking in any Week 4 college football picks for those games or others, be sure to see the latest college football predictions from SportsLine’s advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 4 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 4

One of the college picks the model is high on in Week 4: No. 22 Texas (-6.5) goes on the road and covers against Texas Tech in a 3:30 p.m. ET matchup in Lubbock. The Longhorns have had a roller coaster last two weeks, but they have come away with positives from both games. They nearly pulled off an improbable upset against top-ranked Alabama two weeks ago, easily covering the 21-point spread.

Texas looked as if it was going to fall victim to a trap game last week, as UTSA took a 17-7 lead in the second quarter. The Longhorns responded by scoring 34 of the next 37 points in a 41-20 win, covering the spread as 13-point favorites. Junior running back Bijan Robinson rushed for 183 yards and three touchdowns against UTSA, averaging 9.2 yards per carry.

Robinson is facing a Texas Tech defense that is coming off consecutive games against ranked opponents, allowing at least 27 points in both contests. SportsLine’s model has Robinson rushing for more than 110 yards and a touchdown on Saturday afternoon, which is one reason why Texas is covering the spread in well over 60% of simulations. 

Another one of the model’s college football picks: No. 7 USC goes on the road and covers the 6.5-point spread against Oregon State in a 9:30 p.m. ET start. The Trojans are averaging 50.7 points per game this season under head coach Lincoln Riley. USC is also playing well on defense, giving up just 19.7 points per game. 

The Trojans are coming off an emphatic 45-17 win over Fresno State at home last week thanks to a dominant ground game. Running backs Austin Jones and Travis Dye combined for over 200 rushing yards and two touchdowns. Quarterback Caleb Williams also scored two rushing touchdowns and finished with 284 passing yards and two TDs. Williams will now look to dissect an Oregon State defense that’s giving up 215.3 passing yards per game, which ranks 10th in the Pac-12. Plus, USC has won four of its last five games against Oregon State, one of the main reasons the model expects the Trojans to cover nearly 70% of the time. See which other teams the model likes here.

How to make college football picks for Week 4

The model has also made the call on who wins and covers in every other FBS matchup in Week 4, and it says a Top 25 favorite will go down hard in one of the week’s biggest games. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which Top 25 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned more than $3,300 in profit over the past six-plus seasons, and find out.

College football odds for Week 4 (via Caesars)

See full Week 4 college football picks, odds, predictions here

Thursday, Sept. 22

West Virginia at Virginia Tech (+2.5, 50.5)

Featured Game | Virginia Tech Hokies vs. West Virginia Mountaineers

Coastal Carolina at Georgia State (+2, 62)

Featured Game | Georgia State Panthers vs. Coastal Carolina Chanticleers

Friday, Sept. 23

Virginia at Syracuse (-9.5, 54.5)

Featured Game | Syracuse Orange vs. Virginia Cavaliers

Nevada at Air Force (-24.5, 48.5)

Featured Game | Air Force Falcons vs. Nevada Wolf Pack

Boise State at UTEP (+16, 46.5)

Featured Game | UTEP Miners vs. Boise State Broncos

Saturday, Sept. 24

Kent State at Georgia (-44, 59.5)

Maryland at Michigan (-17, 62.5)

Featured Game | Michigan Wolverines vs. Maryland Terrapins

Central Michigan at Penn State (-26, 60.5)

Featured Game | Penn State Nittany Lions vs. Central Michigan Chippewas

Clemson at Wake Forest (+7, 56.5)

Featured Game | Wake Forest Demon Deacons vs. Clemson Tigers

Baylor at Iowa State (-3, 44.5)

Featured Game | Iowa State Cyclones vs. Baylor Bears

Florida at Tennessee (-10.5, 63.5)

Featured Game | Tennessee Volunteers vs. Florida Gators

Texas at Texas Tech (+5, 60)

Featured Game | Texas Tech Red Raiders vs. Texas Longhorns

Tulsa at Ole Miss (-20, 63)

Featured Game | Ole Miss Rebels vs. Tulsa Golden Hurricane

Oregon at Washington State (+6, 53.5)

Featured Game | Washington State Cougars vs. Oregon Ducks

Northern Illinois at Kentucky (-25.5, 53)

Featured Game | Kentucky Wildcats vs. Northern Illinois Huskies

Arkansas at Texas A&M (-2.5, 48)

Featured Game | Texas A&M Aggies vs. Arkansas Razorbacks

Wisconsin at Ohio State (-18, 56.5)

Featured Game | Ohio State Buckeyes vs. Wisconsin Badgers

Vanderbilt at Alabama (-40.5, 59)

Kansas State at Oklahoma (-13, 53.5)

Featured Game | Oklahoma Sooners vs. Kansas State Wildcats

USC at Oregon State (+6.5, 68)

Featured Game | Oregon State Beavers vs. USC Trojans

Utah at Arizona State (+15, 52)

Featured Game | Arizona State Sun Devils vs. Utah Utes

Stanford at Washington (-12, 61)

Featured Game | Washington Huskies vs. Stanford Cardinal

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