College football odds, picks, predictions for Aug. 27, 2022: Computer simulation fading Illinois in Week 0

August 27, 2022Last Updated: August 27, 2022

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There might not be any ranked college football matchups in Week 0, but there are several intriguing games on Saturday. The first FBS slate of the season kicks off when Nebraska faces Northwestern in Ireland at 12:30 p.m. ET, and it continues with a matchup between Illinois and Wyoming at 4 p.m. ET. Saturday’s slate concludes when Vanderbilt travels to Hawaii in a 10:30 p.m. ET start in Honolulu that will be aired on CBS Sports Network. The Commodores opened as 4.5-point road favorites at Caesars Sportsbook, but they are now 9.5-point favorites in the latest Week 0 college football odds.

Hawaii parted ways with Todd Graham in the offseason, bringing in Timmy Chang to lead his alma mater. Chang is coaching a roster that lost its top passer, top rusher and top receiver, so should you be fading the Rainbow Warriors with your Week 0 college football bets? Before locking in any college football picks for Week 0 of the 2022 season, be sure to see the latest college football predictions from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It also finished the 2021-22 college football season on a 43-31 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest college football odds for Saturday from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Aug. 27, 2022

One of the top college football picks the model is recommending for Saturday: Wyoming (+14) stays within the spread against Illinois in a 4 p.m. ET kickoff on Saturday in Champaign. The Cowboys are not going to be scared by an Illini offense that finished dead last in the Big Ten in passing last season.

Illinois brought in a new offensive coordinator and is expected to start Syracuse transfer Tommy DeVito at quarterback, but the Illini are going to need some time to fix an attack that ranked outside the top 110 nationally in total offense and scoring last year. Wyoming tends to play low-scoring games, anyway, using ball control and tough defense to keep games close. The Cowboys have not faced a Power Five program since knocking off Missouri to open the 2019 season, so they will be motivated by this opportunity.

They have some momentum entering the 2022 campaign after picking up a win over Kent State in the Famous Idaho Potato Bowl last year. Utah State transfer Andrew Peasley could be an upgrade at the quarterback position, while running back Titus Swen returns after a strong 2021 season. SportsLine’s model projects Wyoming’s rushing attack to record more than 160 yards on the ground as the Cowboys are covering the spread in 60% of simulations. See which other teams the model likes here.

How to make college football picks for Saturday, Aug. 27

The model has also made the call on who wins and covers in every other FBS matchup on Saturday, and it’s calling for a big favorite to go down hard in a shocking upset. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which heavy favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,600 in profit over the past six seasons, and find out.